What we do.
Our lab studies unconventional roles for DNA damage repair pathways in regulating cancer growth and response to treatment. We use genomics, transcriptomics and proteomics on patient samples to generate hypotheses that we can test using molecular biology techniques in our lab.
- Svasti Haricharan
DNA Damage Repair and Breast Cancer
We are currently identifying how growth factor receptors in breast cancer cells are displayed, regulated, and activated in DNA damage repair deficient breast cancer cells.
MLH1 Mutations: Pan-Cancer Role
We are currently uncovering how genomic mutations in MLH1 are influencing response to standard of care therapies across multiple cancer cell types including Breast, Prostate, and Colon.
Role of Chk2 Mutations in Endocrine Therapy Resistance
We previously reported that endocrine therapy resistance in MMR deficient cells was due to the lack of activation of Chk2. In this project we are identifying which mutations in Chk2 would abrogate function leading to endocrine therapy resistance and which alternative therapy is viable for cancers containing those mutations.